Evolution of pyrrolidine-type asymmetric organocatalysts by "click" chemistry.

@article{Luo2006EvolutionOP,
  title={Evolution of pyrrolidine-type asymmetric organocatalysts by "click" chemistry.},
  author={Sanzhong Luo and Hui Xu and Xueling Mi and Jiuyuan Li and Xiaoxi Zheng and Jin-Pei Cheng},
  journal={The Journal of organic chemistry},
  year={2006},
  volume={71 24},
  pages={9244-7}
}
Click chemistry has been employed to construct a library of the pyrrolidine-type asymmetric organocatalysts. The clicked organocatalysts were evaluated in asymmetric Michael addition of ketones to nitroolefins, showing good catalytic activity and stereoselectivity (up to 100% yield, syn:anti = 99:1, 96% ee).