Evolution of psychopharmacology trial design and analysis: six decades in the making.

Abstract

OBJECTIVE The evolution of trial design and analysis during the lifespan of psychopharmacology is examined. BACKGROUND The clinical trial methodology used to evaluate psychopharmacologic agents has evolved considerably over the past 6 decades. The first and most productive decade was characterized by case series, each with a small number of patients… (More)
DOI: 10.4088/JCP.10r06669

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