Evolution of protein structural classes and protein sequence families.

  title={Evolution of protein structural classes and protein sequence families.},
  author={In-Geol Choi and Sung-Hou Kim},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={103 38},
In protein structure space, protein structures cluster into four elongated regions when mapped based solely on similarity among the 3D structures. These four regions correspond to the four major classes of present-day proteins defined by the contents of secondary structure types and their topological arrangement. Evolution of and restriction to these four classes suggest that, in most cases, the evolution of genes may have been constrained or selected to those genetic changes that results in… CONTINUE READING
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