Evolution of protein sequences and structures.

@article{Wood1999EvolutionOP,
  title={Evolution of protein sequences and structures.},
  author={Tim C. Wood and William R. Pearson},
  journal={Journal of molecular biology},
  year={1999},
  volume={291 4},
  pages={977-95}
}
The relationship between sequence similarity and structural similarity has been examined in 36 protein families with five or more diverse members whose structures are known. The structural similarity within a family (as determined with the DALI structure comparison program) is linearly related to sequence similarity (as determined by a Smith-Waterman search of the protein sequences in the structure database). The correlation between structural similarity and sequence similarity is very high; 18… CONTINUE READING

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