Evolution of primate α and θ defensins revealed by analysis of genomes

@article{Li2014EvolutionOP,
  title={Evolution of primate $\alpha$ and $\theta$ defensins revealed by analysis of genomes},
  author={Diyan Li and Long Zhang and Huadong Yin and Huai-liang Xu and Jessica Satkoski Trask and David George Smith and Y. Li and Mingyao Yang and Qing Zhu},
  journal={Molecular Biology Reports},
  year={2014},
  volume={41},
  pages={3859-3866}
}
Abstract Defensins are endogenous peptides with cysteine-rich antimicrobial ability that contribute to host defence against bacterial, fungal and viral infections. There are three subfamilies of defensins in primates: α, β and θ-defensins. α-defensins are most present in neutrophils and Paneth cells; β-defensins are involved in protecting the skin and the mucous membranes of the respiratory, genitourinary and gastrointestinal tracts; and θ-defensins are physically distinguished as the only… Expand
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TLDR
The small size, unique structure, and multiple host defense activities of θ-defensins make them intriguing potential therapeutic agents. Expand
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TLDR
Examination of nucleotide substitutions between recently duplicated mammaliandefensin genes shows that the rate of nonsynonymous (amino-acid-altering) substitution exceeds that of synonymous substitution in the region of the gene encoding the mature defensin, evidence that natural selection has acted to diversify defensins at the amino acid level. Expand
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TLDR
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TLDR
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