Evolution of predetermined germ cells in vertebrate embryos: implications for macroevolution.

  title={Evolution of predetermined germ cells in vertebrate embryos: implications for macroevolution.},
  author={Andrew D. Johnson and Matthew Drum and Rosemary F. Bachvarova and Thomas Masi and Mary E. White and Brian I. Crother},
  journal={Evolution & development},
  volume={5 4},
The germ line is established in animal embryos with the formation of primordial germ cells (PGCs), which give rise to gametes. Therefore, the need to form PGCs can act as a developmental constraint by inhibiting the evolution of embryonic patterning mechanisms that compromise their development. Conversely, events that stabilize the PGCs may liberate these constraints. Two modes of germ cell determination exist in animal embryos: (a) either PGCs are predetermined by the inheritance of germ cell… CONTINUE READING

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