Evolution of polyhydroxyalkanoate (PHA) production system by "enzyme evolution": successful case studies of directed evolution.

@article{Taguchi2004EvolutionOP,
  title={Evolution of polyhydroxyalkanoate (PHA) production system by "enzyme evolution": successful case studies of directed evolution.},
  author={Seiichi Taguchi and Yoshihiro Doi},
  journal={Macromolecular bioscience},
  year={2004},
  volume={4 3},
  pages={
          146-56
        }
}
Biotechnological studies towards the biosynthesis of polyhydroxyalkanoates (PHAs) biopolyesters have extensively progressed through the development of various metabolic engineering strategies. Historically, efficient PHA production has been achieved using the fermentation technology of naturally occurring PHA-producing bacteria based on external substrate manipulation (1st generation), and subsequent reinforcement with recombinant gene technology (2nd generation). More recently, "enzyme… CONTINUE READING
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