Evolution of poliovirus type I during 5.5 years of prolonged enteral replication in an immunodeficient patient.


Poliovirus type 1 was isolated from an immunodeficient patient 4 days after onset of paresis (IS1) and after 5.5 years of prolonged enteral virus replication (IS2). Antigenic characterization revealed that IS1 was Sabin 1-like, whereas IS2 reacted like poliovirus 1 Mahoney. Complete genomic sequencing demonstrated the phylogenetic relationship (94.9… (More)


Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.