Evolution of novel small-molecule therapeutics targeting sickle cell vasculopathy.

@article{Kato2008EvolutionON,
  title={Evolution of novel small-molecule therapeutics targeting sickle cell vasculopathy.},
  author={Gregory J. Kato and Mark T Gladwin},
  journal={JAMA},
  year={2008},
  volume={300 22},
  pages={2638-46}
}
A 34-year-old African American woman with sickle cell disease and history of relatively severe hemolysis, chronic leg ulcers, and mild pulmonary hypertension presented with a new ischemic stroke. Recent research has suggested a syndrome of hemolysis-associated vasculopathy in patients with sickle cell disease, which features severe hemolytic anemia and leads to scavenging of nitric oxide and its biochemical precursor l-arginine. This diminished bioavailability of nitric oxide promotes a… CONTINUE READING