Evolution of neurotransmitter receptor systems

@article{Venter1988EvolutionON,
  title={Evolution of neurotransmitter receptor systems},
  author={J. Craig Venter and Umberto di Porzio and D. A. Robinson and S. Martin Shreeve and Josephine Lai and Anthony R Kerlavage and Stephen P. Fracek and K. U. Lentes and Claire M. Fraser},
  journal={Progress in Neurobiology},
  year={1988},
  volume={30},
  pages={105-169}
}
The presence of hormones, neurotransmitters, their receptors and biosynthetic and degradative enzymes is clearly not only associated with the present and the recent past but with the past several hundred million years. Evidence is mounting which indicates substantial conservation of protein structure and function of these receptors and enzymes over these tremendous periods of time. These findings indicate that the evolution and development of the nervous system was not dependent upon the… Expand
Evolutionary aspects of transmitter molecules, their receptors and channels.
TLDR
Although ligand-gated receptors differ markedly in terms of the endogenous ligands they recognize and the ion channels that they gate, the structural similarities suggest a strong evolutionary relationship, and the study of the pharmacology of receptor proteins for neurotransmitters in invertebrates is now gathering momentum. Expand
Chemical Signaling Systems in Lower Organisms: A Prelude to the Evolution of Chemical Communication in the Nervous System
TLDR
The use of chemoreceptors to monitor chemicals appearing in the external environment has many similarities to the use of neuronal receptors to monitor drugs appearing in a synaptic cleft, and analogies between external and internal receptors are described. Expand
5-Hydroxytryptamine receptors in vertebrates and invertebrates: Why are there so many?
  • S. Peroutka
  • Medicine, Biology
  • Neurochemistry International
  • 1994
TLDR
The "primordial" 5-HT receptor appears to have appeared prior to the evolution of muscarinic, dopaminergic and adrenergic receptor systems, which means that the fact that the primordial 5- HT receptor evolved prior to other G protein-coupled biogenic amine receptors may be the reason that so many5-HT receptors exist today. Expand
The molecular evolution of G protein-coupled receptors: Focus on 5-hydroxytryptamine receptors
TLDR
The first "primordial" 5-HT receptor evolved over 750 million years ago, a date which likely predates the evolution of muscarinic, dopaminergic and adrenergic receptor systems, and it is predicted that a significant number of both mammalian and invertebrate G protein-coupled 5- HT receptor subtypes remain to be identified. Expand
The Phylogenetic Background of Neurotransmitters in the Unicellular Organism Tetrahymena Pyriformis
TLDR
The results support the theory that any evolved nervous system-like interplay could stem from a common origin and provide evidence that the chief regulatory molecules of the CNS can be identified even in lower, eukaryotic unicellular levels of phylogeny and possibly alter the basic functions of these organisms. Expand
Pharmacology of a Locust Thoracic Ganglion Somal Nicotinic Acetylcholine Receptor
The dramatic increase in the number of highly-specific new receptor-binding drugs together with a flood of receptor amino acid sequences has revealed differences among receptor types hitherto thoughtExpand
Peptidergic neurons in the vertebrate spinal cord: evolutionary trends.
TLDR
This chapter attempts to illustrate some trends in the evolution of spinal peptidergic neurons, by comparing the molecular and anatomical features of systems that have been characterized in mammals and in non-mammals. Expand
Comparative Molecular Neurobiology
TLDR
The electrophysiological pharmacology of neurotransmitter receptors on locust neuronal somata and Modulation of insect neurone properties are studied. Expand
Chemosensory Systems in Lower Organisms: Correlations with Internal Receptor Systems for Neurotransmitters and Hormones
The presence of specific chemical substances in the environment evokes behavioral responses in many lower eukaryotic organisms such as protozoans and invertebrates (for reviews, see Mackie and GrantExpand
Chapter 9. Peripheral Actions of Selective Muscarinic Agonists and Antagonists
TLDR
The chapter discusses the pharacological properties and therapeutic efficacy of pirenzepine, the first M1-antagonist introduced in toulcer-therapy, and the structural requirements or selectivity towards the muscarinic receptor have been discussed as well as those for M 1-selectivity. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 513 REFERENCES
Multiple Nature of Acetylcholinesterase in Nerve Tissue
TLDR
Data on the unitary or multiple nature of acetylcholinesterase in nervous tissue might lead to specific information on the relation of the enzyme to the nerve conduction process, or might shed light on the general problem of the physiological meaning of the occurrence of multiple molecular enzyme species. Expand
The evolutionary origins of hormones, neurotransmitters, and other extracellular chemical messengers: implications for mammalian biology.
TLDR
Each hormonal peptide was traditionally considered a unique product of a single cell type that was localized in distribution to a limited region of the body known as an endocrine gland, but other cell types have also been recognized as possible sources of peptide hormones. Expand
G proteins and dual control of adenylate cyclase
TLDR
It is clear that detailed understanding of the mechanism of regulation of CAMP synthesis will soon be achieved from study of the interactions of purified components that have been reconstituted in lipid bilayers of defined composition. Expand
The pharmacology of molluscan neurons
TLDR
The biphasic response of the molluscan neurons to neurotransmitters was the first demonstration of the plastic synaptic changes and the discovery of individual neurons with their groups of follower cells acting as chemical units has provided an insight into the organization of various behavioral acts. Expand
The Role of Cyclic Nucleotides in Invertebrates
This chapter presents data supporting a possible role for cyclic nucleotides in neurotransmitter- and hormone-mediated events in invertebrates. Although a large number of studies are described,Expand
Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin
TLDR
Cloning of the gene and cDNA for the mammalian β2AR indicates significant amino-acid homology with bovine rhodopin and suggests that, like rhodopsin7, βAR possesses multiple membrane-spanning regions. Expand
THE PHARMACOLOGICAL DIFFERENTIATION OF ADRENERGIC RECEPTORS *
  • R. Furchgott
  • Chemistry, Medicine
  • Annals of the New York Academy of Sciences
  • 1967
TLDR
The Ahlquist classification has been applied with greatest success to adrenergic receptors of various smooth muscles and heart and met the challenge that a third type of adrenergic receptor was responsible for mediating inhibition of intestinal smooth muscle. Expand
A study of the adrenotropic receptors.
  • R. Ahlquist
  • Chemistry, Medicine
  • The American journal of physiology
  • 1948
TLDR
Experiments described in this paper indicate that although there are two kinds of adrenotropic receptors they cannot be classified simply as excitatory or inhibitory since each kind of receptor may have either action depending upon where it is found. Expand
Biogenic Amines in the Insect Nervous System
TLDR
This chapter takes a view of biogenic amines in the insect nervous system and to assess critically the evidence for their roles as neurotransmitters, neuromodulators and neurohormones. Expand
Acetylcholine receptors in the central nervous system of Drosophila melanogaster.
  • E. Rudloff
  • Biology, Medicine
  • Experimental cell research
  • 1978
TLDR
Evidence was obtained for the presence of acetylcholine receptors in the central nervous system of Drosophila and autoradiographic analyses show that bound toxin is associated only with the neuropile of larvae, pupae and adults, both within the brain and the thoracic ganglion. Expand
...
1
2
3
4
5
...