Evolution of neoplastic development in the liver of transgenic mice co-expressing c-myc and transforming growth factor-alpha.

@article{SantoniRugiu1996EvolutionON,
  title={Evolution of neoplastic development in the liver of transgenic mice co-expressing c-myc and transforming growth factor-alpha.},
  author={Eric Santoni-Rugiu and Peter A. J. Nagy and Michael Rugaard Jensen and Valentina M. Factor and Snorri Thorgeirsson},
  journal={The American journal of pathology},
  year={1996},
  volume={149 2},
  pages={407-28}
}
We have previously shown that co-expression of c-myc and transforming growth factor (TGF)-alpha as transgenes in mouse liver results in major enhancement of neoplastic development in this organ as compared with expression of either of these transgenes alone. In this report we describe in detail the progression from liver cell dysplasia to hepatocellular carcinomas (HCCs) occurring in the liver of c-myc/TGF-alpha and c-myc transgenic mice. Despite morphological similarities in the sequence of… CONTINUE READING