Evolution of methicillin-resistant Staphylococcus aureus towards increasing resistance.

@article{Strommenger2014EvolutionOM,
  title={Evolution of methicillin-resistant Staphylococcus aureus towards increasing resistance.},
  author={Birgit Strommenger and Mette Damkj{\ae}r Bartels and Kevin Kurt and Franziska Layer and Susanne Mie Rohde and Kit Boye and Henrik Westh and Wolfgang Witte and Herminia de Lencastre and Ulrich N{\"u}bel},
  journal={The Journal of antimicrobial chemotherapy},
  year={2014},
  volume={69 3},
  pages={
          616-22
        }
}
OBJECTIVES To elucidate the evolutionary history of Staphylococcus aureus clonal complex (CC) 8, which encompasses several globally distributed epidemic lineages, including hospital-associated methicillin-resistant S. aureus (MRSA) and the highly prevalent community-associated MRSA clone USA300. METHODS We reconstructed the phylogeny of S. aureus CC8 by mutation discovery at 112 genetic housekeeping loci from each of 174 isolates, sampled on five continents between 1957 and 2008. The… CONTINUE READING

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