Evolution of metal(loid) binding sites in transcriptional regulators.


Expression of the genes for resistance to heavy metals and metalloids is transcriptionally regulated by the toxic ions themselves. Members of the ArsR/SmtB family of small metalloregulatory proteins respond to transition metals, heavy metals, and metalloids, including As(III), Sb(III), Cd(II), Pb(II), Zn(II), Co(II), and Ni(II). These homodimeric repressors… (More)
DOI: 10.1074/jbc.M803209200


8 Figures and Tables