Evolution of metabolic diversity: insights from microbial polyketide synthases.


Polyketides are a family of complex natural products that are built from simple carboxylic acid building blocks. In microorganisms, the majority of these secondary metabolites are produced by exceptionally large, multifunctional proteins termed polyketide synthases (PKSs). Each unit of a type I PKS assembly line resembles a mammalian type fatty acid… (More)
DOI: 10.1016/j.phytochem.2009.05.021


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