Evolution of macromolecular import pathways in mitochondria, hydrogenosomes and mitosomes

@article{Lithgow2010EvolutionOM,
  title={Evolution of macromolecular import pathways in mitochondria, hydrogenosomes and mitosomes},
  author={Trevor J Lithgow and Andr{\'e} Schneider},
  journal={Philosophical Transactions of the Royal Society B: Biological Sciences},
  year={2010},
  volume={365},
  pages={799 - 817}
}
  • T. Lithgow, A. Schneider
  • Published 12 March 2010
  • Biology
  • Philosophical Transactions of the Royal Society B: Biological Sciences
All eukaryotes require mitochondria for survival and growth. The origin of mitochondria can be traced down to a single endosymbiotic event between two probably prokaryotic organisms. Subsequent evolution has left mitochondria a collection of heterogeneous organelle variants. Most of these variants have retained their own genome and translation system. In hydrogenosomes and mitosomes, however, the entire genome was lost. All types of mitochondria import most of their proteome from the cytosol… 

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References

SHOWING 1-10 OF 159 REFERENCES

Unique aspects of mitochondrial biogenesis in trypanosomatids.

  • A. Schneider
  • Biology
    International journal for parasitology
  • 2001

Origin and Evolution of the Mitochondrial Proteome

TLDR
There are no phylogenetic indications either in the mitochondrial proteome or in the nuclear genomes that the initial or subsequent function of the ancestor to the mitochondria was anaerobic, and there are indications that relatively advanced eukaryotes adapted to anaerobiosis by dismantling their mitochondria and refitting them as hydrogenosomes.

Bacterial proteins predisposed for targeting to mitochondria.

TLDR
A family of proteins whose members exist both in bacteria and in mitochondria of eukaryotes are analyzed and it is shown that the amino-terminal extensions occasionally found in bacterial family members can function as a crude import sequence when the protein is presented to isolated mitochondria.

The ins and outs of tRNA transport

TLDR
It is now well established that a variable number of tRNA species present in the mitochondria are indeed nucleus‐encoded, and the roles of some of these transport systems have yet to be defined.

Evolution of the Molecular Machines for Protein Import into Mitochondria

TLDR
In creating mitochondria some 2 billion years ago, the first eukaryotes needed to establish protein import machinery in the membranes of what was a bacterial endosymbiont, but the protein translocases that drive protein import into mitochondria have no obvious counterparts in bacteria, making it likely that these machines were created de novo.

Analysis of Two Genomes from the Mitochondrion-Like Organelle of the Intestinal Parasite Blastocystis: Complete Sequences, Gene Content, and Genome Organization

TLDR
Analysis of the characteristics displayed by the unique Blastocystis organelle genome gives an insight into the initial evolutionary steps that may have led from mitochondria to hydrogenosomes and mitosomes via degenerative evolution.

An anaerobic mitochondrion that produces hydrogen

TLDR
It is shown that the hydrogenosomes of the anaerobic ciliate Nyctotherus ovalis, which thrives in the hindgut of cockroaches, have retained a rudimentary genome encoding components of a mitochondrial electron transport chain.

On the origin of mitochondria: a genomics perspective.

TLDR
The strong relationship with alpha-proteobacterial genes observed for some mitochondrial genes, combined with the lack of such a relationship for others, indicates that the modern mitochondrial proteome is the product of both reductive and expansive processes.

Mammalian mitochondria have the innate ability to import tRNAs by a mechanism distinct from protein import

TLDR
It is shown that both tRNAGln species and a bacterial pre-tRNAAsp can be imported in vitro into mitochondria isolated from myoclonic epilepsy with ragged-red fiber cells if provided with sufficient ATP.
...