Evolution of macrolide resistance in Streptococcus pneumoniae clinical isolates in the prevaccine era.

@article{Daikos2008EvolutionOM,
  title={Evolution of macrolide resistance in Streptococcus pneumoniae clinical isolates in the prevaccine era.},
  author={Georgios L. Daikos and Anastasia Koutsolioutsou and Sotirios Tsiodras and Maria Theodoridou and Emmanouil I. Koutouzis and Athina Charissiadou and Anastasia M Pangalis and A Michos and Fotini Chaidopoulou and Maria Braoudaki and Vassiliki P. Syriopoulou},
  journal={Diagnostic microbiology and infectious disease},
  year={2008},
  volume={60 4},
  pages={393-8}
}
Six hundred twelve invasive and noninvasive Streptococcus pneumoniae isolates were examined. Serogrouping was performed by the latex agglutination test and serotyping by the quellung reaction. Susceptibilities to macrolides were determined by Etest. The presence of mef(A), mef(E), and erm(B) genes were detected by polymerase chain reaction. Outpatient macrolide and lincosamide consumption was expressed in defined daily doses per 1000 inhabitants daily (DID). A significant increase in macrolide… CONTINUE READING