Evolution of lamivudine resistance in human immunodeficiency virus type 1-infected individuals: the relative roles of drift and selection.

@article{Frost2000EvolutionOL,
  title={Evolution of lamivudine resistance in human immunodeficiency virus type 1-infected individuals: the relative roles of drift and selection.},
  author={Simon D. W. Frost and Monique Nijhuis and Rob Schuurman and Charles A. Boucher and Andrew J. Leigh Brown},
  journal={Journal of virology},
  year={2000},
  volume={74 14},
  pages={6262-8}
}
Human immunodeficiency virus type 1 (HIV-1) rapidly develops resistance to lamivudine during monotherapy, typically resulting in the appearance at position 184 in reverse transcriptase (RT) of isoleucine instead of the wild-type methionine (M184I) early in therapy, which is later replaced by valine (M184V). M184V reduces viral susceptibility to drug in vitro by approximately 100-fold, but also results in a lower processivity of RT. We show that a drop in absolute viral fitness associated with… CONTINUE READING

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