Evolution of intratumoral genetic heterogeneity during colorectal cancer progression.

@article{Losi2005EvolutionOI,
  title={Evolution of intratumoral genetic heterogeneity during colorectal cancer progression.},
  author={Lorena Losi and B{\'e}n{\'e}dicte Baisse and Hanifa Bouzour{\`e}ne and Jean Benhattar},
  journal={Carcinogenesis},
  year={2005},
  volume={26 5},
  pages={916-22}
}
Evolution of intratumoral genetic heterogeneity during colorectal tumor progression has not been investigated so far. Multiple sample areas in colorectal adenocarcinoma at early and advanced stages and in metastases were studied for the well-known genetic alterations: K-ras and p53 point mutations and loss of heterozygosity (LOH) on chromosomes 5q and 18q. In primary colorectal cancers (CRCs), intratumoral genetic heterogeneity was more often observed in early than in advanced stages, at 90 and… CONTINUE READING

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Genomic instability and cancer.

Current molecular medicine • 2003

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