Evolution of increased complexity in a molecular machine

  title={Evolution of increased complexity in a molecular machine},
  author={Gregory C. Finnigan and Victor Hanson-Smith and Tom H. Stevens and Joseph W. Thornton},
Many cellular processes are carried out by molecular ‘machines’—assemblies of multiple differentiated proteins that physically interact to execute biological functions. Despite much speculation, strong evidence of the mechanisms by which these assemblies evolved is lacking. Here we use ancestral gene resurrection and manipulative genetic experiments to determine how the complexity of an essential molecular machine—the hexameric transmembrane ring of the eukaryotic V-ATPase proton pump—increased… CONTINUE READING
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Ancestral Sequence Reconstruction (Oxford

  • Liberles, D. ed
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