Evolution of homeobox genes

@article{Holland2013EvolutionOH,
  title={Evolution of homeobox genes},
  author={Peter W. H. Holland},
  journal={Wiley Interdisciplinary Reviews: Developmental Biology},
  year={2013},
  volume={2}
}
  • P. Holland
  • Published 2013
  • Biology
  • Wiley Interdisciplinary Reviews: Developmental Biology
Many homeobox genes encode transcription factors with regulatory roles in animal and plant development. Homeobox genes are found in almost all eukaryotes, and have diversified into 11 gene classes and over 100 gene families in animal evolution, and 10 to 14 gene classes in plants. The largest group in animals is the ANTP class which includes the well‐known Hox genes, plus other genes implicated in development including ParaHox (Cdx, Xlox, Gsx), Evx, Dlx, En, NK4, NK3, Msx, and Nanog. Genomic… 
Comprehensive comparative homeobox gene annotation in human and mouse
TLDR
Manual annotation of all homeobox genes and their antisense genes in human and in mouse is set out, finding some discrepancies with the current gene set in RefSeq regarding exact gene structures and coding versus pseudogene locus biotype.
Evolution of Homeobox Gene Clusters in Animals: The Giga-Cluster and Primary vs. Secondary Clustering
TLDR
There is uncertainty in the understanding of homeobox gene cluster evolution at present, so a major goal is to deduce whether particular instances of clustering are primary (conserved from ancient ancestral clusters) or secondary (reassortment of genes into clusters in lineage-specific fashion).
Genome-wide identification, expansion, and evolution analysis of homeobox genes and their expression profiles during root development in carrot
TLDR
This study provided a useful basis for further studies on the complexity and function of the homeobox gene family in carrot and indicated that members of the WOX and KNOX subfamilies were likely implicated in carrot root development.
Hox genes, evo-devo, and the case of the ftz gene
TLDR
This Memorial article series review events around the discovery of the broad evolutionary conservation of Hox genes and the impact of this discovery on the field of developmental biology highlights studies carried out in Walter Gehring's lab and by former lab members that have continued to push the field forward.
Origins and evolvability of the PAX family.
Evolutionary origin and functional divergence of totipotent cell homeobox genes in eutherian mammals
TLDR
It is concluded that a dynamic chromosome region spawned a set of evolutionarily new homeobox genes, the ETCHbox genes, specifically in eutherian mammals, which permitted fine-tuning of cell fate decisions necessary for specification and function of embryonic and extra-embryonic tissues utilised in mammalian development and pregnancy.
Characterization and target genes of nine human PRD-like homeobox domain genes expressed exclusively in early embryos
TLDR
The data implicate a role for these previously uncharacterized PRD-like homeodomain proteins in the regulation of human embryo genome activation and preimplantation embryo development.
An Overview of Hox Genes in Lophotrochozoa: Evolution and Functionality
TLDR
The data presented here suggest that at least nine genes were present while two other genes, Lox4 and Post-2, may either have been present in the ancestor or may have arisen as a result of duplication in the Brachiopoda-Mollusca-Annelida lineage.
Mouse Obox and Crxos modulate preimplantation transcriptional profiles revealing similarity between paralogous mouse and human homeobox genes
TLDR
Mouse Crxos and human ARGFX homeobox genes are paralogous rather than orthologous, yet they have evolved to regulate a common set of genes, suggesting there was compensation of function alongside gene loss through co-option of a different locus.
Identification and characterization of homeobox (Hox) genes and conservation of the single Hox cluster (324.6 kb) in the water flea Daphnia magna
TLDR
The structural array and transcribed orientation of Dm-Hox genes were identical to those of the sister species D. pulex, indicating that the Hox gene structure in daphnids is highly conserved.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 113 REFERENCES
Homeodomain subtypes and functional diversity.
TLDR
Homeobox genes perform key roles for all aspects of the development of an organism, and several particular types of homeodomain proteins play roles in the determination of cell fates and cell differentiation.
Comprehensive Analysis of Animal TALE Homeobox Genes: New Conserved Motifs and Cases of Accelerated Evolution
TLDR
A comprehensive analysis provides a defining framework for the classification of animal TALE homeobox genes and the understanding of their evolution and a novel class is identified, termed MOHAWK (MKX).
Chromosomal mapping of ANTP class homeobox genes in amphioxus: piecing together ancestral genomes
TLDR
It is inferred that clustering of ANTP class homeobox genes evolved just once, during a series of extensive cis‐duplication events of genes early in animal evolution.
Comprehensive survey and classification of homeobox genes in the genome of amphioxus, Branchiostoma floridae
TLDR
The analysis reveals not only the repertoire of amphioxus homeobox genes but also gives insight into the evolution of chordate homeOBox genes.
A low diversity of ANTP class homeobox genes in Placozoa
TLDR
The low diversity of ANTP class genes isolated in Trichoplax can be reconciled with the low anatomical complexity of this animal, although the finding that these genes are assignable to recognized gene families is intriguing.
The Rhox genes.
TLDR
The founding member of the Rhox gene cluster--Rhox5 (previously known as Pem)--has been studied in the most depth and thus is the focus of this review.
...
1
2
3
4
5
...