• DOI:10.1038/42701
Corpus ID: 4351382

Evolution of high mutation rates in experimental populations of E. coli

@article{Sniegowski1997EvolutionOH,
  title={Evolution of high mutation rates in experimental populations of E. coli},
  author={Paul Sniegowski and Philip J. Gerrish and Richard E. Lenski},
  journal={Nature},
  year={1997},
  volume={387},
  pages={703-705}
}

Paul Sniegowski, Philip J. Gerrish, Richard E. Lenski

Published 1997

Biology, Medicine

Nature

Most mutations are likely to be deleterious, and so the spontaneous mutation rate is generally held at a very low value. Nonetheless, evolutionary theory predicts that high mutation rates can evolve under certain circumstances. Empirical observations have previously been limited to short-term studies of the fates of mutator strains deliberately introduced into laboratory populations of Escherichia coli, and to the effects of intense selective events on mutator frequencies in E. coli. Here we… CONTINUE READING

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