Evolution of high mutation rates in experimental populations of E. coli

@article{Sniegowski1997EvolutionOH,
  title={Evolution of high mutation rates in experimental populations of E. coli},
  author={P. Sniegowski and P. Gerrish and R. Lenski},
  journal={Nature},
  year={1997},
  volume={387},
  pages={703-705}
}
  • P. Sniegowski, P. Gerrish, R. Lenski
  • Published 1997
  • Biology, Medicine
  • Nature
  • Most mutations are likely to be deleterious, and so the spontaneous mutation rate is generally held at a very low value. Nonetheless, evolutionary theory predicts that high mutation rates can evolve under certain circumstances. Empirical observations have previously been limited to short-term studies of the fates of mutator strains deliberately introduced into laboratory populations of Escherichia coli, and to the effects of intense selective events on mutator frequencies in E. coli. Here we… CONTINUE READING
    821 Citations

    Figures and Topics from this paper

    Explore Further: Topics Discussed in This Paper

    Mutation rate dynamics in a bacterial population reflect tension between adaptation and genetic load
    • 189
    • PDF
    Tempo and mode of genome evolution in a 50,000-generation experiment
    • 279
    • PDF
    Evolution of mutation rates in bacteria
    • 312
    • PDF

    References

    SHOWING 1-10 OF 33 REFERENCES
    COMPETITION BETWEEN HIGH AND LOW MUTATING STRAINS OF ESCHERICHIA COLI
    • L. Chao, E. Cox
    • Biology, Medicine
    • Evolution; international journal of organic evolution
    • 1983
    • 258
    Dynamics of adaptation and diversification: a 10,000-generation experiment with bacterial populations.
    • R. Lenski, M. Travisano
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1994
    • 855
    • PDF
    Natural Selection and Mutability
    • E. Leigh
    • Biology
    • The American Naturalist
    • 1970
    • 209
    Adaptive evolution of highly mutable loci in pathogenic bacteria
    • 740
    • PDF