Evolution of high mutation rates in experimental populations of E. coli
@article{Sniegowski1997EvolutionOH, title={Evolution of high mutation rates in experimental populations of E. coli}, author={P. Sniegowski and P. Gerrish and R. Lenski}, journal={Nature}, year={1997}, volume={387}, pages={703-705} }
Most mutations are likely to be deleterious, and so the spontaneous mutation rate is generally held at a very low value. Nonetheless, evolutionary theory predicts that high mutation rates can evolve under certain circumstances. Empirical observations have previously been limited to short-term studies of the fates of mutator strains deliberately introduced into laboratory populations of Escherichia coli, and to the effects of intense selective events on mutator frequencies in E. coli. Here we… CONTINUE READING
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