Evolution of high-level ethambutol-resistant tuberculosis through interacting mutations in decaprenylphosphoryl-β-D-arabinose biosynthetic and utilization pathway genes

@article{Safi2013EvolutionOH,
  title={Evolution of high-level ethambutol-resistant tuberculosis through interacting mutations in decaprenylphosphoryl-β-D-arabinose biosynthetic and utilization pathway genes},
  author={Hassan Safi and Subramanya Lingaraju and Anita G. Amin and Soyeon Kim and M. Tim Jones and Michael Holmes and Michael A. McNeil and Scott N. Peterson and Delphi Chatterjee and Robert Fleischmann and David Alland},
  journal={Nature Genetics},
  year={2013},
  volume={45},
  pages={1190-1197}
}
To study the evolution of drug resistance, we genetically and biochemically characterized Mycobacterium tuberculosis strains selected in vitro for ethambutol resistance. Mutations in decaprenylphosphoryl-β-D-arabinose (DPA) biosynthetic and utilization pathway genes Rv3806c, Rv3792, embB and embC accumulated to produce a wide range of ethambutol minimal… CONTINUE READING
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