Evolution of hepatitis C viral quasispecies after liver transplantation.

  title={Evolution of hepatitis C viral quasispecies after liver transplantation.},
  author={Andr{\'e} de Castro Lyra and Xiaofeng Fan and Dorothy M. Lang and Karina Yusim and Sanjay Ramrakhiani and Elizabeth M. Brunt and Bette T Korber and Alan S. Perelson and Adrian M Di Bisceglie},
  volume={123 5},
BACKGROUND & AIMS To determine whether HCV quasispecies diversity correlated positively with liver disease progression after orthotopic liver transplantation (OLT). METHODS We studied 11 patients undergoing OLT for HCV-related cirrhosis with recurrent hepatitis C in 2 groups according to the stage of hepatic fibrosis on follow-up. The mild group had stage 1 or 2 fibrosis; the severe group, stage 3 or 4 fibrosis. HCV quasispecies diversity was assessed by cloning and sequencing in… CONTINUE READING


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