Evolution of hemopoietic ligands and their receptors. Influence of positive selection on correlated replacements throughout ligand and receptor proteins.

@article{Shields1996EvolutionOH,
  title={Evolution of hemopoietic ligands and their receptors. Influence of positive selection on correlated replacements throughout ligand and receptor proteins.},
  author={Denis C. Shields and Dawn L Harmon and Alexander S. Whitehead},
  journal={Journal of immunology},
  year={1996},
  volume={156 3},
  pages={1062-70}
}
The rates of amino acid replacement in cytokines and their receptors are high and vary considerably. To determine whether this reflects the action of positive selection, rates of nonsynonymous DNA substitution were examined and found to exceed the synonymous substitution rate in certain exons of rodent IL-3, granulocyte-macrophage stimulating factor, and IL-4. To determine the extent to which positive selection could account for correlations between the amino acid replacement rates of… CONTINUE READING