Evolution of heat shock protein and immunity.

  title={Evolution of heat shock protein and immunity.},
  author={Jacques Robert},
  journal={Developmental and comparative immunology},
  volume={27 6-7},
  • Jacques Robert
  • Published 2003 in Developmental and comparative immunology
Heat shock proteins (hsps) are among the most abundant intracellular proteins. Their synthesis is rapidly up-regulated by various 'stressors' including temperature, glucose deprivation, infection and cancer. Certain hsps are able to: (i). associate and chaperone a large variety of cellular peptides; (ii). be efficiently internalized by antigen presenting cells (APC) through receptor-mediated endocytosis; (iii). channel antigenic peptides they chaperone in the APC's MHC class I presentation… CONTINUE READING


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