Evolution of functional diversification of the paired box (Pax) DNA-binding domains.

@article{Balczarek1997EvolutionOF,
  title={Evolution of functional diversification of the paired box (Pax) DNA-binding domains.},
  author={Kristi A. Balczarek and Z C Lai and Sudhir Y Kumar},
  journal={Molecular biology and evolution},
  year={1997},
  volume={14 8},
  pages={829-42}
}
The Pax gene family consists of tissue-specific transcriptional regulators that always contain a highly conserved DNA-binding domain with six alpha-helices (paired domain), and, in many cases, a complete or residual homeodomain. Numerous genes of this family have been identified in animals, with the largest number found in vertebrates. Our evolutionary analyses indicate that the vertebrate Pax gene family consists of four well-defined and statistically supported groups: group I (Pax-1, 9), II… CONTINUE READING

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