Evolution of function of a fused metazoan tRNA synthetase.

  title={Evolution of function of a fused metazoan tRNA synthetase.},
  author={Partho Sarothi Ray and James C. Sullivan and Jie Jia and John Francis and John R. Finnerty and Paul L. Fox},
  journal={Molecular biology and evolution},
  volume={28 1},
The origin and evolution of multidomain proteins are driven by diverse processes including fusion/fission, domain shuffling, and alternative splicing. The 20 aminoacyl-tRNA synthetases (AARS) constitute an ancient conserved family of multidomain proteins. The glutamyl-prolyl tRNA synthetase (EPRS) of bilaterian animals is unique among AARSs, containing two functional enzymes catalyzing ligation of glutamate and proline to their cognate transfer RNAs (tRNAs). The ERS and PRS catalytic domains in… 

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