Evolution of exon-intron structure and alternative splicing in fruit flies and malarial mosquito genomes.

@article{Malko2006EvolutionOE,
  title={Evolution of exon-intron structure and alternative splicing in fruit flies and malarial mosquito genomes.},
  author={Dmitry B. Malko and Vsevolod J. Makeev and Andrey A. Mironov and Mikhail S. Gelfand},
  journal={Genome research},
  year={2006},
  volume={16 4},
  pages={505-9}
}
Comparative analysis of alternative splicing of orthologous genes from fruit flies (Drosophila melanogaster and Drosophila pseudoobscura) and mosquito (Anopheles gambiae) demonstrated that both in the fruit fly genes and in fruit fly-mosquito comparisons, constitutive exons and splicing sites are more conserved than alternative ones. While >97% of constitutive D. melanogaster exons are conserved in D. pseudoobscura, only approximately 80% of alternative exons are conserved. Similarly, 77% of… CONTINUE READING

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