Evolution of enzyme structure

@article{Hartley1979EvolutionOE,
  title={Evolution of enzyme structure},
  author={B. Hartley},
  journal={Proceedings of the Royal Society of London. Series B. Biological Sciences},
  year={1979},
  volume={205},
  pages={443 - 452}
}
  • B. Hartley
  • Published 1979
  • Biology, Medicine
  • Proceedings of the Royal Society of London. Series B. Biological Sciences
Three-dimensional structures of enzymes offer evidence about their evolution. There are clear examples of divergent families (e. g. mammalian serine proteases) and convergence (e. g. chymotrypsin and subtilisin). Topological similarities in dehydrogenases may reflect an ancient divergence or merely chemical constraints on protein architectures. Further experimental evidence is desirable to back up arguments based on molecular morphology. By growing microorganisms on novel foodstuffs in a… Expand
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