Evolution of drug-resistant mutations in HBV genomes in patients with treatment failure during the past seven years (2010–2016)

@article{Zhang2017EvolutionOD,
  title={Evolution of drug-resistant mutations in HBV genomes in patients with treatment failure during the past seven years (2010–2016)},
  author={Hong-Yu Zhang and Long-gen Liu and Chun-yan Ye and Chun-hua Chen and Shuang-xiong Hang and Zhen Zhu and Hong-yu Shen and Ze-yu Huang and Wen-Yi Chen and Yuan Xue},
  journal={Virus Genes},
  year={2017},
  volume={54},
  pages={41-47}
}
The objective of this study was to analyze the prevalence of drug-resistant HBV mutants in patients with treatment failure during the past seven years (2010–2016). 4055 HBV-infected patients who underwent HBV polymerase gene mutation test from 2010 to 2016 were enrolled. The nucleos(t)ide analogues (NAs) resistance mutation positions, including rtL180, rtA181, rtT184, rtS202, rtM204, rtI233, rtN236, rtI169, rtV173, and rtM250 were analyzed. Genotypic resistance mutations were detected in 30.8… CONTINUE READING

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