Evolution of diterpene metabolism: Sitka spruce CYP720B4 catalyzes multiple oxidations in resin acid biosynthesis of conifer defense against insects.

@article{Hamberger2011EvolutionOD,
  title={Evolution of diterpene metabolism: Sitka spruce CYP720B4 catalyzes multiple oxidations in resin acid biosynthesis of conifer defense against insects.},
  author={Bj{\"o}rn Hamberger and Toshiyuki Ohnishi and Britta Hamberger and Armand S{\'e}guin and Joerg Bohlmann},
  journal={Plant physiology},
  year={2011},
  volume={157 4},
  pages={1677-95}
}
Diterpene resin acids (DRAs) are specialized (secondary) metabolites of the oleoresin defense of conifers produced by diterpene synthases and cytochrome P450s of the CYP720B family. The evolution of DRA metabolism shares common origins with the biosynthesis of ent-kaurenoic acid, which is highly conserved in general (primary) metabolism of gibberellin biosynthesis. Transcriptome mining in species of spruce (Picea) and pine (Pinus) revealed CYP720Bs of four distinct clades. We cloned a… CONTINUE READING

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