Evolution of distinct EGF domains with specific functions.

@article{Wouters2005EvolutionOD,
  title={Evolution of distinct EGF domains with specific functions.},
  author={Merridee A. Wouters and Isidore Rigoutsos and Carmen K Chu and Lina L. Feng and Duncan B Sparrow and Sally L. Dunwoodie},
  journal={Protein science : a publication of the Protein Society},
  year={2005},
  volume={14 4},
  pages={
          1091-103
        }
}
EGF domains are extracellular protein modules cross-linked by three intradomain disulfides. Past studies suggest the existence of two types of EGF domain with three-disulfides, human EGF-like (hEGF) domains and complement C1r-like (cEGF) domains, but to date no functional information has been related to the two different types, and they are not differentiated in sequence or structure databases. We have developed new sequence patterns based on the different C-termini to search specifically for… CONTINUE READING

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