Evolution of distinct EGF domains with specific functions

  title={Evolution of distinct EGF domains with specific functions},
  author={M. A. Wouters and I. Rigoutsos and C. K. Chu and L. Feng and D. Sparrow and S. Dunwoodie},
  journal={Protein Science},
  • M. A. Wouters, I. Rigoutsos, +3 authors S. Dunwoodie
  • Published 2005
  • Medicine, Chemistry
  • Protein Science
  • EGF domains are extracellular protein modules cross‐linked by three intradomain disulfides. Past studies suggest the existence of two types of EGF domain with three‐disulfides, human EGF‐like (hEGF) domains and complement C1r‐like (cEGF) domains, but to date no functional information has been related to the two different types, and they are not differentiated in sequence or structure databases. We have developed new sequence patterns based on the different C‐termini to search specifically for… CONTINUE READING
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