Evolution of cytochrome oxidase, an enzyme older than atmospheric oxygen.

  title={Evolution of cytochrome oxidase, an enzyme older than atmospheric oxygen.},
  author={Jose Castresana and Mathias L{\"u}bben and Matti Saraste and Desmond G. Higgins},
  journal={The EMBO journal},
  volume={13 11},
Cytochrome oxidase is a key enzyme in aerobic metabolism. All the recorded eubacterial (domain Bacteria) and archaebacterial (Archaea) sequences of subunits 1 and 2 of this protein complex have been used for a comprehensive evolutionary analysis. The phylogenetic trees reveal several processes of gene duplication. Some of these are ancient, having occurred in the common ancestor of Bacteria and Archaea, whereas others have occurred in specific lines of Bacteria. We show that eubacterial quinol… CONTINUE READING


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