Evolution of crystallins for a role in the vertebrate eye lens

@article{Slingsby2013EvolutionOC,
  title={Evolution of crystallins for a role in the vertebrate eye lens},
  author={C. Slingsby and G. Wistow and A. R. Clark},
  journal={Protein Science},
  year={2013},
  volume={22}
}
The camera eye lens of vertebrates is a classic example of the re‐engineering of existing protein components to fashion a new device. The bulk of the lens is formed from proteins belonging to two superfamilies, the α‐crystallins and the βγ‐crystallins. Tracing their ancestry may throw light on the origin of the optics of the lens. The α‐crystallins belong to the ubiquitous small heat shock proteins family that plays a protective role in cellular homeostasis. They form enormous polydisperse… Expand
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