Evolution of context dependent regulation by expansion of feast/famine regulatory proteins

@inproceedings{Plaisier2014EvolutionOC,
  title={Evolution of context dependent regulation by expansion of feast/famine regulatory proteins},
  author={Christopher Plaisier and Fang-Yin Lo and Justin Ashworth and Aaron N. Brooks and Karlyn D. Beer and Amardeep Kaur and Min Pan and David J. Reiss and Marc T. Facciotti and Nitin S. Baliga},
  booktitle={BMC Systems Biology},
  year={2014}
}
Expansion of transcription factors is believed to have played a crucial role in evolution of all organisms by enabling them to deal with dynamic environments and colonize new environments. We investigated how the expansion of the Feast/Famine Regulatory Protein (FFRP) or Lrp-like proteins into an eight-member family in Halobacterium salinarum NRC-1 has aided in niche-adaptation of this archaeon to a complex and dynamically changing hypersaline environment. We mapped genome-wide binding… CONTINUE READING
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