Evolution of complementary nucleotides in 5' and 3' untranslated regions of influenza A virus genomic segments.

@article{Suzuki2013EvolutionOC,
  title={Evolution of complementary nucleotides in 5' and 3' untranslated regions of influenza A virus genomic segments.},
  author={Yoshiyuki Suzuki and Yuki Kobayashi},
  journal={Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases},
  year={2013},
  volume={13},
  pages={175-9}
}
The genome of influenza A virus comprises 8 segments (segments 1-8) of single-stranded RNA (virion RNA: vRNA) with negative-polarity. All vRNAs share 13 and 12 terminal nucleotides in the 5' and 3' untranslated regions (UTRs), respectively, which are partially complementary and constitute panhandle and corkscrew structures. Here, it is shown, from the analysis of genomic sequences for 506 strains of influenza A virus, that the number of contiguous complementary nucleotides in the 5' and 3' UTRs… CONTINUE READING