Evolution of cnidarian trans‐defensins: Sequence, structure and exploration of chemical space

@article{Mitchell2019EvolutionOC,
  title={Evolution of cnidarian trans‐defensins: Sequence, structure and exploration of chemical space},
  author={Michela L Mitchell and Thomas M A Shafee and Anthony T. Papenfuss and Raymond S. Norton},
  journal={Proteins: Structure},
  year={2019},
  volume={87},
  pages={551 - 560}
}
Many of the small, cysteine‐rich ion‐channel modulatory peptides found in Cnidaria are distantly related to vertebrate defensins (of the trans‐defensin superfamily). Transcriptomic and proteomic studies of the endemic Australian speckled sea anemone (Oulactis sp.) yielded homologous peptides to known defensin sequences. We extended these data using existing and custom‐built hidden Markov models to extract defensin‐like families from the transcriptomes of seven endemic Australian cnidarian… Expand
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