Evolution of closely linked gene pairs in vertebrate genomes.

@article{Franck2008EvolutionOC,
  title={Evolution of closely linked gene pairs in vertebrate genomes.},
  author={Erik Franck and Tim Hulsen and Martijn A. Huynen and Wilfried W. de Jong and N. H. Lubsen and Ole Madsen},
  journal={Molecular biology and evolution},
  year={2008},
  volume={25 9},
  pages={
          1909-21
        }
}
The orientation of closely linked genes in mammalian genomes is not random: there are more head-to-head (h2h) gene pairs than expected. To understand the origin of this enrichment in h2h gene pairs, we have analyzed the phylogenetic distribution of gene pairs separated by less than 600 bp of intergenic DNA (gene duos). We show here that a lack of head-to-tail (h2t) gene duos is an even more distinctive characteristic of mammalian genomes, with the platypus genome as the only exception. In… 

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