Evolution of closely linked gene pairs in vertebrate genomes.

@article{Franck2008EvolutionOC,
  title={Evolution of closely linked gene pairs in vertebrate genomes.},
  author={E. Franck and Tim Hulsen and M. Huynen and W. D. de Jong and N. Lubsen and O. Madsen},
  journal={Molecular biology and evolution},
  year={2008},
  volume={25 9},
  pages={
          1909-21
        }
}
  • E. Franck, Tim Hulsen, +3 authors O. Madsen
  • Published 2008
  • Biology, Medicine
  • Molecular biology and evolution
  • The orientation of closely linked genes in mammalian genomes is not random: there are more head-to-head (h2h) gene pairs than expected. To understand the origin of this enrichment in h2h gene pairs, we have analyzed the phylogenetic distribution of gene pairs separated by less than 600 bp of intergenic DNA (gene duos). We show here that a lack of head-to-tail (h2t) gene duos is an even more distinctive characteristic of mammalian genomes, with the platypus genome as the only exception. In… CONTINUE READING
    16 Citations

    Figures, Tables, and Topics from this paper

    Explore Further: Topics Discussed in This Paper

    Sorting out inherent features of head-to-head gene pairs by evolutionary conservation
    • 4
    • PDF
    Neighboring Genes Show Correlated Evolution in Gene Expression
    • 72
    • PDF
    DLGP: A database for lineage-conserved and lineage-specific gene pairs in animal and plant genomes.
    • D. Wang
    • Biology, Medicine
    • Biochemical and biophysical research communications
    • 2016
    The Evolution of Functional Gene Clusters in Eukaryote Genomes
    • 2
    • Highly Influenced
    DBH2H: vertebrate head-to-head gene pairs annotated at genomic and post-genomic levels
    • Hui Yu, F. Yu, +4 authors Y. Li
    • Biology, Computer Science
    • Database J. Biol. Databases Curation
    • 2009
    • 4
    • PDF
    Evolutionary conservation of neighbouring gene pairs in plants.
    • 19
    • PDF
    Bidirectional promoters in the transcription of mammalian genomes
    • 31

    References

    SHOWING 1-10 OF 39 REFERENCES
    Evolutionary origin and maintenance of coexpressed gene clusters in mammals.
    • 146
    • PDF
    Complex Loci in Human and Mouse Genomes
    • 288
    • PDF
    Origins of bidirectional promoters: computational analyses of intergenic distance in the human genome.
    • 73
    • PDF
    Genomic organization of transcriptomes in mammals: Coregulation and cofunctionality.
    • 66
    • PDF
    Origin of avian genome size and structure in non-avian dinosaurs
    • 239
    • PDF
    Systematic Analysis of Head-to-Head Gene Organization: Evolutionary Conservation and Potential Biological Relevance
    • 127
    • PDF
    Comparative sequencing provides insights about the structure and conservation of marsupial and monotreme genomes.
    • 80
    • PDF
    Tandem chimerism as a means to increase protein complexity in the human genome.
    • 199
    • PDF