Evolution of carbohydrate antigens--microbial forces shaping host glycomes?

  title={Evolution of carbohydrate antigens--microbial forces shaping host glycomes?},
  author={Joseph R. Bishop and Pascal Gagneux},
  volume={17 5},
Many glycans show remarkably discontinuous distribution across evolutionary lineages. These differences play major roles when organisms belonging to different lineages interact as host-pathogen or host-symbiont. Certain lineage-specific glycans have become important signals for multicellular host organisms, which use them as molecular signatures of their pathogens and symbionts through recognition by a toolkit of innate defense molecules. In turn, pathogens have evolved to exploit host lineage… CONTINUE READING
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Essentials of glycobiology

  • A Varki, R Cummings, JD Esko, HF Freeze, GW Hart, JD. Marth
  • Cold Spring Harbor Laboratory Press, Plainview…
  • 1999
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