Evolution of blood coagulation activators and inhibitors in the healthy human fetus.

@article{ReverdiauMoalic1996EvolutionOB,
  title={Evolution of blood coagulation activators and inhibitors in the healthy human fetus.},
  author={Pascale Reverdiau-Moalic and B{\'e}n{\'e}dicte Delahousse and Gilles Body and Pierre Bardos and J{\'e}r{\^o}me Leroy and Yves Gruel},
  journal={Blood},
  year={1996},
  volume={88 3},
  pages={900-6}
}
Blood coagulation proteins were determined in 285 healthy fetuses from 19 to 38 weeks' gestation and compared with those of 60 normal full-term newborns and 40 adult controls. Prolongation of the coagulation screening tests, prothrombin time, activated partial prothrombin time, and thrombin clotting time, in fetuses throughout intrauterine life was explained by low levels of vitamin K-dependent factors (II, VII, IX, and X), contact factors (XI, XII, prekallikrein, and high-molecular-weight… CONTINUE READING