Evolution of biological sequences implies an extreme value distribution of type I for both global and local pairwise alignment scores

@article{Bastien2007EvolutionOB,
  title={Evolution of biological sequences implies an extreme value distribution of type I for both global and local pairwise alignment scores},
  author={Olivier Bastien and Eric Mar{\'e}chal},
  journal={BMC Bioinformatics},
  year={2007},
  volume={9},
  pages={332 - 332}
}
Confidence in pairwise alignments of biological sequences, obtained by various methods such as Blast or Smith-Waterman, is critical for automatic analyses of genomic data. Two statistical models have been proposed. In the asymptotic limit of long sequences, the Karlin-Altschul model is based on the computation of a P-value, assuming that the number of high scoring matching regions above a threshold is Poisson distributed. Alternatively, the Lipman-Pearson model is based on the computation of a… CONTINUE READING
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