Evolution of bioinorganic motifs in P450-containing systems.

  title={Evolution of bioinorganic motifs in P450-containing systems.},
  author={Kirill Degtyarenko and Tamara Kulikova},
  journal={Biochemical Society transactions},
  volume={29 Pt 2},
The choice of bioinorganic motifs by Nature results in a spectacular variety of active-site structures even within the same protein family. Here, we use the concept of the bioinorganic motif to discuss the function and evolution of P450-containing and other related systems. Apart from P450, these systems include a FAD flavoprotein or domain, a FMN domain, ferredoxins and cytochrome b(5). Analysis of available complete genomes can shed light on what an ancestral P450-containing system could be. 

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Nucleic Acids Res

  • A. Bairoch, R. Apweiler
  • Nucleic Acids Res
  • 2000

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