Evolution of biocatalysis 1. Possible pre-genetic-code RNA catalysts which are their own replicase

@article{Visser2004EvolutionOB,
  title={Evolution of biocatalysis 1. Possible pre-genetic-code RNA catalysts which are their own replicase},
  author={Cornelis M. Visser},
  journal={Origins of life},
  year={2004},
  volume={14},
  pages={291-300}
}
  • C. Visser
  • Published 2004
  • Biology, Chemistry
  • Origins of life
A search for a possible chemical mechanism for pre-genetic-code phosphorylation, phosphoric anhydride formation and subsequent evolution of catalysts based upon oligoribonucleotides has resulted in a plausible scheme for pre-genetic-code evolution of self-replicating catalysts, independent of coded polypeptides. Only known chemistry of extant cofactors (coenzymes and prosthetic groups) and models thereof has been used for construction of this theoretical scheme. 

Cofactors are Remnants of Life’s Origin and Early Evolution

TLDR
Evidence from prebiotic geochemistry, ribozyme biochemistry, and evolutionary biology, increasingly supports hypotheses that certain coenzymes and cofactors may bridge modern biology with the past and can thus provide insights into the elusive and poorly-recorded period of the origin and early evolution of life.

The use of bonding between tRNAs to implement early peptide synthesis

  • P. Wood
  • Biology
    Journal of Molecular Evolution
  • 2005
SummaryContinuation of early evolutionary bonding between tRNAs would provide a solution to residence time problems between peptidyl-tRNA and mRNA. It could also improve the speed of peptide bond

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