Evolution of bacteria specialization along an antibiotic dose gradient

  title={Evolution of bacteria specialization along an antibiotic dose gradient},
  author={No{\'e}mie Harmand and Romain Gallet and Guillaume Martin and Thomas Lenormand},
  booktitle={Evolution letters},
Antibiotic and pesticide resistance of pathogens are major and pressing worldwide issues. Resistance evolution is often considered in simplified ecological contexts: treated versus nontreated environments. In contrast, antibiotic usually present important dose gradients: from ecosystems to hospitals to polluted soils, in treated patients across tissues. However, we do not know whether adaptation to low or high doses involves different phenotypic traits, and whether these traits trade-off with… CONTINUE READING
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