Evolution of an Expanded Mannose Receptor Gene Family

  title={Evolution of an Expanded Mannose Receptor Gene Family},
  author={Karen A. Staines and Lawrence G. Hunt and John Young and Colin Butter},
  booktitle={PloS one},
Sequences of peptides from a protein specifically immunoprecipitated by an antibody, KUL01, that recognises chicken macrophages, identified a homologue of the mammalian mannose receptor, MRC1, which we called MRC1L-B. Inspection of the genomic environment of the chicken gene revealed an array of five paralogous genes, MRC1L-A to MRC1L-E, located between conserved flanking genes found either side of the single MRC1 gene in mammals. Transcripts of all five genes were detected in RNA from a… CONTINUE READING
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