Evolution of alternative biosynthetic pathways for vitamin C following plastid acquisition in photosynthetic eukaryotes

@inproceedings{Wheeler2015EvolutionOA,
  title={Evolution of alternative biosynthetic pathways for vitamin C following plastid acquisition in photosynthetic eukaryotes},
  author={Glen E. Wheeler and Takahiro Ishikawa and Varissa Pornsaksit and Nicholas Smirnoff},
  booktitle={eLife},
  year={2015}
}
Ascorbic acid (vitamin C) is an enzyme co-factor in eukaryotes that also plays a critical role in protecting photosynthetic eukaryotes against damaging reactive oxygen species derived from the chloroplast. Many animal lineages, including primates, have become ascorbate auxotrophs due to the loss of the terminal enzyme in their biosynthetic pathway, L-gulonolactone oxidase (GULO). The alternative pathways found in land plants and Euglena use a different terminal enzyme, L-galactonolactone… CONTINUE READING
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