Evolution of a tumorigenic property conferred by glycophosphatidyl-inositol membrane anchors of carcinoembryonic antigen gene family members during the primate radiation.

Abstract

GPI membrane anchors of cell surface glycoproteins have been shown to confer functional properties that are different from their transmembrane (TM)-anchored counterparts. For the human carcinoembryonic antigen (CEA) family, a subfamily of the immunoglobulin superfamily, conversion of the mode of membrane linkage from TM to GPI confers radical changes in… (More)

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@article{Naghibalhossaini2007EvolutionOA, title={Evolution of a tumorigenic property conferred by glycophosphatidyl-inositol membrane anchors of carcinoembryonic antigen gene family members during the primate radiation.}, author={Fakhraddin Naghibalhossaini and Anne D. Yoder and Martin Tobi and Clifford Paul Stanners}, journal={Molecular biology of the cell}, year={2007}, volume={18 4}, pages={1366-74} }