Evolution of Viral DNA-Dependent DNA Polymerases

@article{Knopf2004EvolutionOV,
  title={Evolution of Viral DNA-Dependent DNA Polymerases},
  author={C. W. Knopf},
  journal={Virus Genes},
  year={2004},
  volume={16},
  pages={47-58}
}
  • C. W. Knopf
  • Published 2004
  • Biology, Medicine
  • Virus Genes
  • DNA viruses as their host cells require a DNA-dependent DNA polymerase (Pol) to faithfully replicate their genomic information. Large eukaryotic DNA viruses as well as bacterial viruses encode a specific Pol equipped with a proofreading 3′-5′-exonuclease, and other replication proteins. All known viral Pol belong to family A and family B Pol. Common to all viral Pol is the conservation of the 3′-5′-exonuclease domain manifested by the three sequence motifs Exo I, Exo II, and Exo III. The… CONTINUE READING
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