Evolution of VHL tumourigenesis in nerve root tissue.

  title={Evolution of VHL tumourigenesis in nerve root tissue.},
  author={Alexander O. Vortmeyer and Maxine G B Tran and Wen-tao Zeng and Sven Glaesker and Clyde Riley and Michael Tsokos and Barbara L. Ikejiri and Marsha J. Merrill and Mark A. Raffeld and Zhengping Zhuang and Russell R. Lonser and Patrick Henry Maxwell and Edward H. Oldfield},
  journal={The Journal of pathology},
  volume={210 3},
Haemangioblastomas are the key central nervous system manifestation of von Hippel-Lindau (VHL) disease, which is caused by germline mutation of the VHL gene. We have recently shown that 'tumour-free' spinal cord from patients with VHL disease contains microscopic, poorly differentiated cellular aggregates in nerve root tissue, which we descriptively designated 'mesenchymal tumourlets'. Here we have investigated spinal cord tissue affected by multiple tumours. We show that a small subset of… CONTINUE READING


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