Evolution of Novel Reassortant A/H3N2 Influenza Viruses in North American Swine and Humans, 2009–2011

@article{Nelson2012EvolutionON,
  title={Evolution of Novel Reassortant A/H3N2 Influenza Viruses in North American Swine and Humans, 2009–2011},
  author={Martha I. Nelson and Amy L. Vincent and Pravina Kitikoon and Edward C. Holmes and Marie Ren{\'e} Gramer},
  journal={Journal of Virology},
  year={2012},
  volume={86},
  pages={8872 - 8878}
}
ABSTRACT Novel H3N2 influenza viruses (H3N2v) containing seven genome segments from swine lineage triple-reassortant H3N2 viruses and a 2009 pandemic H1N1 (H1N1pdm09) matrix protein segment (pM) were isolated from 12 humans in the United States between August and December 2011. To understand the evolution of these novel H3N2 viruses in swine and humans, we undertook a phylogenetic analysis of 674 M sequences and 388 HA and NA sequences from influenza viruses isolated from North American swine… 
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References

SHOWING 1-10 OF 51 REFERENCES
Pathogenicity and Transmission in Pigs of the Novel A(H3N2)v Influenza Virus Isolated from Humans and Characterization of Swine H3N2 Viruses Isolated in 2010-2011
TLDR
In vivo study detected no increased virulence in A(H3N2)v or rH3 n2p viruses compared to endemic H3N 2-TRIG virus, and continued monitoring of these H3n2 viruses is necessary to evaluate the evolution and potential loss of population immunity in swine and humans.
Multiple reassortment between pandemic (H1N1) 2009 and endemic influenza viruses in pigs, United States.
TLDR
Novel reassortant viruses detected in commercial pig farms in the United States highlight the increasing complexity of influenza viruses within pig populations and the frequency at which viral diversification occurs in this ecologically important viral reservoir.
The M Segment of the 2009 New Pandemic H1N1 Influenza Virus Is Critical for Its High Transmission Efficiency in the Guinea Pig Model
TLDR
The data showed that the M segment of the Cal/09 virus promoted aerosol transmissibility to recombinant viruses with PR8 and sw/Tx/98 virus backgrounds, suggesting that theM segment is a critical factor supporting the transmission of the 2009 pandemic virus.
Swine-origin influenza A (H3N2) virus infection in two children--Indiana and Pennsylvania, July-August 2011.
TLDR
Clinicians who suspect influenza virus infection in humans with recent exposure to swine should obtain a nasopharyngeal swab from the patient for timely diagnosis at a state public health laboratory and consider empirical neuraminidase inhibitor antiviral treatment to quickly limit potential human transmission.
Whole-Genome Analysis of Human Influenza A Virus Reveals Multiple Persistent Lineages and Reassortment among Recent H3N2 Viruses
TLDR
A phylogenetic analysis of 156 complete genomes of human H3N2 influenza A viruses collected between 1999 and 2004 from New York State, United States demonstrated that multiple lineages can co-circulate, persist, and reassort in epidemiologically significant ways, and underscore the importance of genomic analyses for future influenza surveillance.
Emergence of novel reassortant H3N2 swine influenza viruses with the 2009 pandemic H1N1 genes in the United States
TLDR
The emergence of novel reassortant H3N2 SIVs demonstrates reassortment between pH1N1 and endemic Sivs in pigs and justifies continuous surveillance.
Pandemic A/H1N1/2009 influenza virus in swine, Cameroon, 2010.
Outbreak of swine influenza in Argentina reveals a non-contemporary human H3N2 virus highly transmissible among pigs.
TLDR
This is the first report of a wholly human H3N2 IAV associated with clinical disease in pigs in South America and highlights the importance of two-way transmission of IAVs and SIVs between pigs and humans, and calls for enhanced influenza surveillance in the pig population worldwide.
Reassortment of Pandemic H1N1/2009 Influenza A Virus in Swine
TLDR
Through systematic surveillance of influenza viruses in swine from a Hong Kong abattoir, a reassortant progeny of H1N1/2009 with swine viruses is characterized, which could produce variants with transmissibility and altered virulence for humans.
Emergence and Dissemination of a Swine H3N2 Reassortant Influenza Virus with 2009 Pandemic H1N1 Genes in Pigs in China
TLDR
This is the first evidence that swine reassortant viruses with pdm/09-like genes may have become established in the field, altering the landscape of human and swine influenza.
...
...